Anti-HSD11B1 Antibody

Rs. 45,619.00
SKU stj29862

General Information

Product name Anti-HSD11B1 Antibody
Short Description Rabbit polyclonal to HSD11B1
Description The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-HSD11B1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 25-292 of human HSD11B1 (NP_005516.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 32.4 kDa
Database Links
Alternative Names HSD11B1Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 antibodyHSD11 antibodyHSD11L antibodySDR26C1
Function Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone, Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol, In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
Cellular Localization Endoplasmic reticulum membrane
Tissue Specificity Widely expressed, highest expression in liver
Swiss-Prot Key

 

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