Anti-HTRA2 Antibody

Rs. 45,619.00
SKU stj28329

General Information

Product name Anti-HTRA2 Antibody
Short Description Rabbit polyclonal to HTRA2
Description This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-HTRA2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 334-458 of human HTRA2 (NP_037379.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 48.8 kDa
Database Links
Alternative Names HTRA2Serine protease HTRA2 antibodymitochondrial HTRA2 antibodyOMI antibodyPRSS25
Function Serine protease that shows proteolytic activity against a non-specific substrate beta-casein, Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism, Cleaves THAP5 and promotes its degradation during apoptosis, Isoform 2 seems to be proteolytically inactive.
Cellular Localization Mitochondrion intermembrane space, Mitochondrion membrane.
Tissue Specificity Isoform 1 is ubiquitous, isoform 2 is expressed predominantly in the kidney, colon and thyroid
Swiss-Prot Key

 

You recently viewed

Clear recently viewed