Anti-HUS1 Antibody

Rs. 45,619.00
SKU stj27360

General Information

Product name Anti-HUS1 Antibody
Short Description Rabbit polyclonal to HUS1
Description The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.
Applications WB,IF,IP
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
IP 1:50 - 1:200
Protein Name Anti-HUS1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human HUS1 (NP_004498.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 31.7 kDa
Database Links
Alternative Names HUS1Checkpoint protein HUS1 antibodyhHUS1HUS1
Function Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair, The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex, Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER), The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds
Cellular Localization Nucleus
Tissue Specificity Ubiquitous.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed