Anti-HYAL1 Antibody

Rs. 45,619.00
SKU stj28706

General Information

Product name Anti-HYAL1 Antibody
Short Description Rabbit polyclonal to HYAL1
Description This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-HYAL1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 136-435 of human HYAL1 (NP_149349.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 48.4 kDa
Database Links
Alternative Names HYAL1Hyaluronidase-1 antibodyHyal-1HYAL1 antibodyLUCA1
Function May have a role in promoting tumor progression, May block the TGFB1-enhanced cell growth.
Cellular Localization Secreted
Tissue Specificity Highly expressed in the liver, kidney and heart, weakly expressed in lung, placenta and skeletal muscle, no expression detected in adult brain, isoform 1 is expressed only in bladder and prostate cancer cells, g2/g3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells, isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.
Swiss-Prot Key

 

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