Anti-HYAL3 Antibody

Rs. 45,619.00
SKU stj29091

General Information

Product name Anti-HYAL3 Antibody
Short Description Rabbit polyclonal to HYAL3
Description This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-HYAL3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 198-417 of human HYAL3 (NP_003540.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 46.5 kDa
Database Links
Alternative Names HYAL3Hyaluronidase-3 antibodyHyal-3HYAL3 antibodyLUCA3
Function Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid, Involved in induction of the acrosome reaction in the sperm, Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate, Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage, Has no hyaluronidase activity in embryonic fibroblasts in vitro, Has no hyaluronidase activity in granulosa cells in vitro.
Cellular Localization Secreted
Tissue Specificity Expressed in sperm.
Swiss-Prot Key

 

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