Anti-IκB-α antibody

Rs. 50,211.00
SKU stj93785

General Information

Product name Anti-IκB-α antibody
Short Description
Description Rabbit polyclonal to IκB-α.
Applications WB,IHC,IF,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000
Protein Name Anti-IκB-α antibody
Immunogen Synthesized peptide derived from human IκB-α around the non-phosphorylation site of Y42.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 36 kDa
Database Links
Alternative Names NF-kappa-B inhibitor alpha antibody
I-kappa-B-alpha antibody
IkB-alpha antibody
IkappaBalpha antibody
Major histocompatibility complex enhancer-binding protein MAD3 antibody
IKBA antibody
MAD3 antibody
NFKBI antibody
Function Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Cellular Localization Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
Tissue Specificity
Swiss-Prot Key

 

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