Anti-IKZF3 Antibody

Rs. 45,619.00
SKU stj29426

General Information

Product name Anti-IKZF3 Antibody
Short Description Rabbit polyclonal to IKZF3
Description This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-IKZF3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 280-450 of human IKZF3 (NP_036613.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 58 kDa
Database Links
Alternative Names IKZF3Zinc finger protein Aiolos antibodyIkaros family zinc finger protein 3IKZF3 antibodyZNFN1A3
Function Transcription factor that plays an important role in the regulation of lymphocyte differentiation, Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state, Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
Cellular Localization Nucleus, Cytoplasm
Tissue Specificity Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.
Swiss-Prot Key

 

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