Anti-IL11RA Antibody

Rs. 45,619.00
SKU stj28710

General Information

Product name Anti-IL11RA Antibody
Short Description Rabbit polyclonal to IL11RA
Description Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-IL11RA Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human IL11RA (NP_001136256.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 45.2 kDa
Database Links
Alternative Names IL11RAInterleukin-11 receptor subunit alpha antibodyIL-11 receptor subunit alpha antibodyIL-11R subunit alpha antibodyIL-11R-alpha antibodyIL-11RAIL11RA
Function Receptor for interleukin-11, The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission, The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells, Essential for the normal development of craniofacial bones and teeth, Restricts suture fusion and tooth number.
Cellular Localization Membrane
Tissue Specificity Expressed in a number of cell lines, including the myelogenous leukemia cell line k-562, the megakaryocytic leukemia cell line m-07e, the erythroleukemia cell line tf-1, and the osteosarcoma cell lines, mg-63 and saos-2, also expressed in normal and malignant prostate epithelial cell lines, expression levels are increased in prostate carcinoma.
Swiss-Prot Key

 

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