Anti-IL1R1 Antibody

Rs. 45,619.00
SKU stj28294

General Information

Product name Anti-IL1R1 Antibody
Short Description Rabbit polyclonal to IL1R1
Description This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-IL1R1 Antibody
Immunogen Recombinant protein of human IL1R1
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 65.4 kDa
Database Links
Alternative Names IL1R1Interleukin-1 receptor type 1 antibodyIL-1R-1 antibodyIL-1RT-1 antibodyIL-1RT1 antibodyCD121 antigen-like family member A antibodyInterleukin-1 receptor alpha antibodyIL-1R-alpha antibodyInterleukin-1 receptor type I antibodyp80 antibodyCD antigen CD121aIL1R1 antibodyIL1R antibodyIL1RA antibodyIL1RT1
Function Receptor for IL1A, IL1B and IL1RN, After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways, Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits, Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex, Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.
Cellular Localization Membrane
Tissue Specificity Expressed in t-helper cell subsets, preferentially expressed in t-helper 1 (th1) cells.
Swiss-Prot Key

 

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