Anti-ILF2 Antibody

Rs. 45,619.00
SKU stj28155

General Information

Product name Anti-ILF2 Antibody
Short Description Rabbit polyclonal to ILF2
Description The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-ILF2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ILF2 (NP_004506.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 43.1 kDa
Database Links
Alternative Names ILF2Interleukin enhancer-binding factor 2 antibodyNuclear factor of activated T-cells 45 kDaILF2 antibodyNF45 antibodyPRO3063
Function Appears to function predominantly as a heterodimeric complex with ILF3, This complex may regulate transcription of the IL2 gene during T-cell activation, It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA, Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus.
Cellular Localization Nucleus, nucleolus, Cytoplasm, Nucleus.
Tissue Specificity
Swiss-Prot Key

 

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