Anti-IMPDH2 Antibody

Rs. 45,619.00
SKU stj27303

General Information

Product name Anti-IMPDH2 Antibody
Short Description Rabbit polyclonal to IMPDH2
Description This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-IMPDH2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 215-514 of human IMPDH2 (NP_000875.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 55.8 kDa
Database Links
Alternative Names IMPDH2Inosine-5'-monophosphate dehydrogenase 2 antibodyIMP dehydrogenase 2 antibodyIMPD 2 antibodyIMPDH 2IMPDH2 antibodyIMPD2
Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth, Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism, It may also have a role in the development of malignancy and the growth progression of some tumors
Cellular Localization Cytoplasm
Tissue Specificity Imp type i is the main species in normal leukocytes and type ii predominates over type i in the tumor
Swiss-Prot Key

 

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