Anti-ING4 Antibody

Rs. 45,619.00
SKU stj28396

General Information

Product name Anti-ING4 Antibody
Short Description Rabbit polyclonal to ING4
Description This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-ING4 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human ING4 (NP_001121054.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 28.5 kDa
Database Links
Alternative Names ING4Inhibitor of growth protein 4 antibodyp29ING4ING4 antibodyMy036
Function Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo, Through chromatin acetylation it may function in DNA replication, May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation, Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA, May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC, Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1), Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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