Anti-INHA Antibody

Rs. 45,619.00
SKU stj27677

General Information

Product name Anti-INHA Antibody
Short Description Rabbit polyclonal to INHA
Description This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-INHA Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 19-366 of human INHA (NP_002182.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 39.7 kDa
Database Links
Alternative Names INHAInhibin alpha chainINHA
Function Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland, Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition, Inhibins appear to oppose the functions of activins
Cellular Localization Secreted
Tissue Specificity Originally found in ovary (granulosa cells) and testis (sertoli cells), but widely distributed in many tissues including brain and placenta, in adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia, also found in adrenocortical tumors, also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer, only circulating inhibin b is found in male, whereas circulating inhibins a and b are found in female.
Swiss-Prot Key

 

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