Anti-INHBA Antibody

Rs. 45,619.00
SKU stj28400

General Information

Product name Anti-INHBA Antibody
Short Description Rabbit polyclonal to INHBA
Description The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-INHBA Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 21-426 of human INHBA (NP_002183.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 47.4 kDa
Database Links
Alternative Names INHBAInhibin beta A chain antibodyActivin beta-A chain antibodyErythroid differentiation protein antibodyEDFINHBA
Function Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland, Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition, Inhibins appear to oppose the functions of activins
Cellular Localization Secreted
Tissue Specificity
Swiss-Prot Key

 

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