Anti-Integrin αV antibody

Rs. 50,211.00
SKU stj93730

General Information

Product name Anti-Integrin αV antibody
Short Description
Description Rabbit polyclonal to Integrin αV.
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000
Protein Name Anti-Integrin αV antibody
Immunogen Synthesized peptide derived from human Integrin αV.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 135 kDa
Database Links
Alternative Names Integrin alpha-V antibody
Vitronectin receptor antibody
Vitronectin receptor subunit alpha antibody
CD antigen CD51 antibody
Integrin alpha-V heavy chain antibody
Integrin alpha-V light chain antibody
MSK8 antibody
VNRA antibody
VTNR antibody
Function The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling . ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling . ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling . ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling . ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 . ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 . (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C . Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for coxsackievirus A9 and B1 . Integrin ITGAV:ITGB3 acts as a receptor for herpes virus 8/HHV-8 . Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1 . Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1 . Integrin ITGAV:ITGB3 acts as a receptor for West nile virus . In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions .
Cellular Localization Membrane. Single-pass type I membrane protein. Cell junction, focal adhesion
Tissue Specificity
Swiss-Prot Key

 

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