Anti-IRAK4 Antibody

Rs. 45,619.00
SKU stj27964

General Information

Product name Anti-IRAK4 Antibody
Short Description Rabbit polyclonal to IRAK4
Description This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-IRAK4 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human IRAK4 (NP_057207.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 51.5 kDa
Database Links
Alternative Names IRAK4Interleukin-1 receptor-associated kinase 4 antibodyIRAK-4IRAK4
Function Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens, Involved in Toll-like receptor (TLR) and IL-1R signaling pathways leading to NF-kappa-B nuclear translocation and activation, Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation, Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.
Cellular Localization Cytoplasm
Tissue Specificity
Swiss-Prot Key

 

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