Anti-ISCU Antibody

Rs. 45,619.00
SKU stj29162

General Information

Product name Anti-ISCU Antibody
Short Description Rabbit polyclonal to ISCU
Description This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold. Fe-S clusters are cofactors that play a role in the function of a diverse set of enzymes, including those that regulate metabolism, iron homeostasis, and oxidative stress response. Alternative splicing results in transcript variants encoding different protein isoforms that localize either to the cytosol or to the mitochondrion. Mutations in this gene have been found in patients with hereditary myopathy with lactic acidosis. A disease-associated mutation in an intron may activate a cryptic splice site, resulting in the production of a splice variant encoding a putatively non-functional protein. A pseudogene of this gene is present on chromosome 1.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-ISCU Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-167 of human ISCU (NP_998760.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 18 kDa
Database Links
Alternative Names ISCUIron-sulfur cluster assembly enzyme ISCU antibodymitochondrial antibodyNifU-like N-terminal domain-containing protein antibodyNifU-like proteinISCU antibodyNIFUN
Function Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.
Cellular Localization Mitochondrion
Tissue Specificity Detected in heart, liver, skeletal muscle, brain, pancreas, kidney, lung and placenta.
Swiss-Prot Key

 

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