Anti-ISL1 Antibody

Rs. 45,619.00
SKU stj28466

General Information

Product name Anti-ISL1 Antibody
Short Description Rabbit polyclonal to ISL1
Description This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-ISL1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-349 of human ISL1 (NP_002193.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 39 kDa
Database Links
Alternative Names ISL1Insulin gene enhancer protein ISL-1 antibodyIslet-1ISL1
Function DNA-binding transcriptional activator, Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes, Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation, Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina, Involved in the specification of motor neurons in cooperation with LHX3 and LDB1, Binds to insulin gene enhancer sequences, Essential for heart development, Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart, Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity).
Cellular Localization Nucleus
Tissue Specificity Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.
Swiss-Prot Key

 

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