Anti-ITGA2 Antibody

Rs. 45,619.00
SKU stj29766

General Information

Product name Anti-ITGA2 Antibody
Short Description Rabbit polyclonal to ITGA2
Description This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:100 - 1:200
IF 1:50 - 1:200
Protein Name Anti-ITGA2 Antibody
Immunogen Recombinant protein of human ITGA2
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 129.3 kDa
Database Links
Alternative Names ITGA2Integrin alpha-2 antibodyCD49 antigen-like family member B antibodyCollagen receptor antibodyPlatelet membrane glycoprotein Ia antibodyGPIa antibodyVLA-2 subunit alpha antibodyCD antigen CD49bITGA2 antibodyCD49B
Function Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin, It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen, It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix
Cellular Localization Membrane
Tissue Specificity
Swiss-Prot Key

 

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