Anti-ITGA6 Antibody

Rs. 45,619.00
SKU stj29899

General Information

Product name Anti-ITGA6 Antibody
Short Description Rabbit polyclonal to ITGA6
Description The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-ITGA6 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 870-1010 of human ITGA6 (NP_001073286.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 126.6 kDa
Database Links
Alternative Names ITGA6Integrin alpha-6 antibodyCD49 antigen-like family member F antibodyVLA-6 antibodyCD antigen CD49fITGA6
Function Integrin alpha-6/beta-1 is a receptor for laminin on platelets, Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity), ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling.
Cellular Localization Cell membrane
Tissue Specificity Integrin alpha-6/beta-4 is predominantly expressed by epithelia, isoforms containing segment x1 are ubiquitously expressed, isoforms containing segment x1x2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines
Swiss-Prot Key

 

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