Anti-ITGAM Antibody

Rs. 45,619.00
SKU stj24251

General Information

Product name Anti-ITGAM Antibody
Short Description Rabbit polyclonal to ITGAM
Description This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-ITGAM Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 20-330 of human ITGAM (NP_001139280.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 127.2 kDa
Database Links
Alternative Names ITGAMIntegrin alpha-M antibodyCD11 antigen-like family member B antibodyCR-3 alpha chain antibodyCell surface glycoprotein MAC-1 subunit alpha antibodyLeukocyte adhesion receptor MO1 antibodyNeutrophil adherence receptor antibodyCD antigen CD11bITGAM antibodyCD11B antibodyCR3A
Function Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles, It is identical with CR-3, the receptor for the iC3b fragment of the third complement component, It probably recognizes the R-G-D peptide in C3b, Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1, It recognizes P1 and P2 peptides of fibrinogen gamma chain, Regulates neutrophil migration.
Cellular Localization Cell membrane
Tissue Specificity Predominantly expressed in monocytes and granulocytes.
Swiss-Prot Key

 

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