Anti-ITGB1 Antibody

Rs. 68,577.00
SKU stj73303

General Information

Product name Anti-ITGB1 Antibody
Short Description Goat polyclonal to ITGB1
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-ITGB1 Antibody
Immunogen Internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 88.4 kDa
Database Links
Alternative Names ITGB1Integrin beta-1 antibodyFibronectin receptor subunit beta antibodyGlycoprotein IIa antibodyGPIIA antibodyVLA-4 subunit beta antibodyCD antigen CD29ITGB1 antibodyFNRB antibodyMDF2 antibodyMSK12
Function Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen, Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen, Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin, Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin, Integrin alpha-5/beta-1 is a receptor for fibrinogen, Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin, Integrin alpha-4/beta-1 is a receptor for VCAM1, It recognizes the sequence Q-I-D-S in VCAM1, Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin, It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin, Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4, Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration, Integrin alpha-V/beta-1 is a receptor for vitronectin, Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands, Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro), When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition, Involved in promoting endothelial cell motility and angiogenesis, Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules, May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1, Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation, Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis, Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion, ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions,
Cellular Localization Cell membrane
Tissue Specificity Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution, isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells, isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines, isoform 4, rather than isoform 3, is selectively expressed in peripheral t-cells, isoform 3 is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines, isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle),
Swiss-Prot Key

 

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