Anti-KAT5 Antibody

Rs. 50,211.00
SKU stj24280

General Information

Product name Anti-KAT5 Antibody
Short Description Rabbit polyclonal to KAT5
Description The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-KAT5 Antibody
Immunogen Recombinant protein of human KAT5
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 58.6 kDa
Database Links
Alternative Names KAT5Histone acetyltransferase KAT5 KAT5 antibodyHTATIP antibodyTIP60
Function Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A, This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription, This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair, NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage, Directly acetylates and activates ATM, Component of a SWR1-like complex that specifically mediates the removal of histone H2A,Z/H2AFZ from the nucleosome, Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2, Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity.
Cellular Localization Nucleus, Nucleus, nucleolus, Cytoplasm, perinuclear region.
Tissue Specificity
Swiss-Prot Key

 

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