Anti-KCNA2 Antibody

Rs. 45,619.00
SKU stj28217

General Information

Product name Anti-KCNA2 Antibody
Short Description Rabbit polyclonal to KCNA2
Description Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-KCNA2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human KCNA2 (NP_001191198.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 56.7 kDa
Database Links
Alternative Names KCNA2Potassium voltage-gated channel subfamily A member 2 antibodyNGK1 antibodyVoltage-gated K(+ antibodychannel HuKIV antibodyVoltage-gated potassium channel HBK5 antibodyVoltage-gated potassium channel subunit Kv1.2KCNA2
Function Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system, Prevents aberrant action potential firing and regulates neuronal output, Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient, The channel alternates between opened and closed conformations in response to the voltage difference across the membrane.
Cellular Localization Cell membrane.
Tissue Specificity Detected in brain cortex.
Swiss-Prot Key

 

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