Anti-KCNN3 Antibody

Rs. 45,619.00
SKU stj27878

General Information

Product name Anti-KCNN3 Antibody
Short Description Rabbit polyclonal to KCNN3
Description Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-KCNN3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 237-426 of human KCNN3 (NP_740752.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 82 kDa
Database Links
Alternative Names KCNN3Small conductance calcium-activated potassium channel protein 3 antibodySK3 antibodySKCa 3 antibodySKCa3 antibodyKCa2.3KCNN3 antibodyK3
Function Forms a voltage-independent potassium channel activated by intracellular calcium, Activation is followed by membrane hyperpolarization, Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization, The channel is blocked by apamin
Cellular Localization Membrane
Tissue Specificity
Swiss-Prot Key

 

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