Anti-KCNQ2/3/4/5 antibody

Rs. 50,211.00
SKU stj93823

General Information

Product name Anti-KCNQ2/3/4/5 antibody
Short Description
Description Rabbit polyclonal to KCNQ2/3/4/5.
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:10000
Protein Name Anti-KCNQ2/3/4/5 antibody
Immunogen Synthesized peptide derived from human KCNQ2/3/4/5 around the non-phosphorylation site of T217/246/223/251.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 96.742 kDa
Database Links
Alternative Names Potassium voltage-gated channel subfamily KQT member 2 antibody
KQT-like 2 antibody
Neuroblastoma-specific potassium channel subunit alpha KvLQT2 antibody
Voltage-gated potassium channel subunit Kv7.2 antibody
Function Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors.
Cellular Localization Membrane. Multi-pass membrane protein.
Tissue Specificity In adult and fetal brain. Highly expressed in areas containing neuronal cell bodies, low in spinal chord and corpus callosum. Isoform 2 is preferentially expressed in differentiated neurons. Isoform 6 is prominent in fetal brain, undifferentiated neuroblastoma cells and brain tumors.
Swiss-Prot Key

 

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