Anti-KDM1A Antibody

Rs. 68,577.00
SKU stj73308

General Information

Product name Anti-KDM1A Antibody
Short Description Goat polyclonal to KDM1A
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-KDM1A Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 92.9 kDa
Database Links
Alternative Names KDM1ALysine-specific histone demethylase 1A KDM1A antibodyAOF2 antibodyKDM1 antibodyKIAA0601 antibodyLSD1
Function Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context, Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed, Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation, Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me, May play a role in the repression of neuronal genes, Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity, Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression, The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A, Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation, Demethylates and stabilizes the DNA methylase DNMT1, Required for gastrulation during embryogenesis, Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development, Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8, Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7,
Cellular Localization Nucleus
Tissue Specificity Ubiquitously expressed,
Swiss-Prot Key

 

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