Anti-KHDRBS1 Antibody

Rs. 45,619.00
SKU stj29932

General Information

Product name Anti-KHDRBS1 Antibody
Short Description Rabbit polyclonal to KHDRBS1
Description This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:100 - 1:200
IF 1:50 - 1:200
Protein Name Anti-KHDRBS1 Antibody
Immunogen A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human KHDRBS1 (NP_006550.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 48.2 kDa
Database Links
Alternative Names KHDRBS1KH domain-containing antibodyRNA-binding antibodysignal transduction-associated protein 1 antibodyGAP-associated tyrosine phosphoprotein p62 antibodySrc-associated in mitosis 68 kDa protein antibodySam68 antibodyp21 Ras GTPase-activating protein-associated p62 antibodyp68KHDRBS1 antibodySAM68
Function Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors, Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins, Role in G2-M progression in the cell cycle, Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP, Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export, Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation, According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to.
Cellular Localization Nucleus
Tissue Specificity Ubiquitously expressed in all tissue examined, isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver.
Swiss-Prot Key

 

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