Anti-KHDRBS2 Antibody

Rs. 45,619.00
SKU stj29933

General Information

Product name Anti-KHDRBS2 Antibody
Short Description Rabbit polyclonal to KHDRBS2
Description
Applications WB,IHC
Dilution range WB 1:500 - 1:1000
IHC 1:100 - 1:200
Protein Name Anti-KHDRBS2 Antibody
Immunogen A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human KHDRBS2 (NP_689901.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 38.9 kDa
Database Links
Alternative Names KHDRBS2KH domain-containing antibodyRNA-binding antibodysignal transduction-associated protein 2 antibodySam68-like mammalian protein 1 antibodySLM-1 antibodyhSLM-1KHDRBS2 antibodySLM1
Function RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion, Binds both poly(A) and poly(U) homopolymers, Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity), Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer, Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners, Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping, In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4, Its phosphorylation by FYN inhibits its ability to regulate splice site selection, May function as an adapter protein for Src kinases during mitosis.
Cellular Localization Nucleus
Tissue Specificity Highly expressed in brain, lung, kidney and small intestine, weakly expressed in placenta, liver, spleen, thymus, ovary and colon.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF