Anti-KIR2DS4 Antibody

Rs. 45,619.00
SKU stj26179

General Information

Product name Anti-KIR2DS4 Antibody
Short Description Rabbit polyclonal to KIR2DS4
Description Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-KIR2DS4 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 22-245 of human KIR2DS4 (NP_036446.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 33.6 kDa
Database Links
Alternative Names KIR2DS4Killer cell immunoglobulin-like receptor 2DS4 antibodyCD158 antigen-like family member I antibodyMHC class I NK cell receptor antibodyNatural killer-associated transcript 8 antibodyNKAT-8 antibodyP58 natural killer cell receptor clones CL-39/CL-17 antibodyp58 NK receptor CL-39/CL-17 antibodyCD antigen CD158iKIR2DS4 antibodyCD158I antibodyKKA3 antibodyNKAT8
Function Receptor on natural killer (NK) cells for HLA-C alleles, Does not inhibit the activity of NK cells.
Cellular Localization Cell membrane
Tissue Specificity
Swiss-Prot Key

 

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