Anti-KLHL12 Antibody

Rs. 61,689.00
SKU stj26949

General Information

Product name Anti-KLHL12 Antibody
Short Description Rabbit polyclonal to KLHL12
Description This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-KLHL12 Antibody
Immunogen A synthetic Peptide of human KLHL12
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 63.3 kDa
Database Links
Alternative Names KLHL12Kelch-like protein 12 antibodyCUL3-interacting protein 1 antibodyDKIR homolog antibodyhDKIRKLHL12 antibodyC3IP1
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.
Cellular Localization Cytoplasmic vesicle, COPII-coated vesicle
Tissue Specificity Ubiquitously expressed, highly expressed in testis and at lower levels in the submandibular salivary gland.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF