Anti-KLHL3 Antibody

Rs. 61,689.00
SKU stj26760

General Information

Product name Anti-KLHL3 Antibody
Short Description Rabbit polyclonal to KLHL3
Description This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-KLHL3 Antibody
Immunogen A synthetic Peptide of human KLHL3
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 65 kDa
Database Links
Alternative Names KLHL3Kelch-like protein 3KLHL3 antibodyKIAA1129
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron.
Cellular Localization Cytoplasm, cytoskeleton
Tissue Specificity Widely expressed.
Swiss-Prot Key

 

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