Anti-SETD8 Antibody

Rs. 45,619.00
SKU stj29444

General Information

Product name Anti-SETD8 Antibody
Short Description Rabbit polyclonal to KMT5A
Description
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-SETD8 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 73-352 of human SETD8 (NP_065115.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 42.9 kDa
Database Links
Alternative Names KMT5AN-lysine methyltransferase KMT5A KMT5A antibodyPRSET7 antibodySET07 antibodySET8 antibodySETD8
Function Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins, Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1), H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression, Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes, Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis, Involved in chromosome condensation and proper cytokinesis, Nucleosomes are preferred as substrate compared to free histones, Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes, Plays a negative role in TGF-beta response regulation and a positive role in cell migration.
Cellular Localization Nucleus, Chromosome, association is increased in a H(2)O(2)-induced oxidative stress-dependent manner, Associates with silent chromatin on euchromatic arms, Not associated with constitutive heterochromatin
Tissue Specificity
Swiss-Prot Key

 

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