Anti-KPNA1 Antibody

Rs. 68,577.00
SKU stj70488

General Information

Product name Anti-KPNA1 Antibody
Short Description Goat polyclonal to KPNA1
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-KPNA1 Antibody
Immunogen N Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 60.2 kDa
Database Links
Alternative Names KPNA1Importin subunit alpha-5 antibodyKaryopherin subunit alpha-1 antibodyNucleoprotein interactor 1 antibodyNPI-1 antibodyRAG cohort protein 2 antibodySRP1-betaKPNA1 antibodyRCH2
Function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1, Binds specifically and directly to substrates containing either a simple or bipartite NLS motif, Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism, At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin, The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus, In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS
Cellular Localization Cytoplasm
Tissue Specificity Expressed ubiquitously
Swiss-Prot Key

 

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