Anti-KPNB1 Antibody

Rs. 68,577.00
SKU stj70816

General Information

Product name Anti-KPNB1 Antibody
Short Description Goat polyclonal to KPNB1
Description
Applications ELISA, WB, IHC
Dilution range
Protein Name Anti-KPNB1 Antibody
Immunogen C Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 97.2 kDa
Database Links
Alternative Names KPNB1Importin subunit beta-1 antibodyImportin-90 antibodyKaryopherin subunit beta-1 antibodyNuclear factor p97 antibodyPore targeting complex 97 kDa subunit antibodyPTAC97KPNB1 antibodyNTF97
Function Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor, Acting autonomously, serves itself as NLS receptor, Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism, At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin, The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus, Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5, Binds to a beta-like import receptor binding (BIB) domain of RPL23A, In association with IPO7 mediates the nuclear import of H1 histone, In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones, In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev, Imports SNAI1 and PRKCI into the nucleus,
Cellular Localization Cytoplasm
Tissue Specificity
Swiss-Prot Key

 

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