Anti-Ku-70 antibody

Rs. 50,211.00
SKU stj93864

General Information

Product name Anti-Ku-70 antibody
Short Description
Description Rabbit polyclonal to Ku-70.
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000
Protein Name Anti-Ku-70 antibody
Immunogen Synthesized peptide derived from human Ku-70
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 70 kDa
Database Links
Alternative Names X-ray repair cross-complementing protein 6 antibody
5'-deoxyribose-5-phosphate lyase Ku70 antibody
5'-dRP lyase Ku70 antibody
70 kDa subunit of Ku antigen antibody
ATP-dependent DNA helicase 2 subunit 1 antibody
ATP-dependent DNA helicase II 70 kDa subunit antibody
CTC box-binding factor 75 kDa subunit antibody
CTC75 antibody
CTCBF antibody
DNA repair protein XRCC6 antibody
Lupus Ku autoantigen protein p70 antibody
Ku70 antibody
Thyroid-lupus autoantigen antibody
TLAA antibody
X-ray repair complementing defective repair in Chinese hamster cells 6 antibody
G22P1 antibody
Function Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.
Cellular Localization Nucleus Chromosome
Tissue Specificity
Swiss-Prot Key

 

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