Anti-Ku-86 antibody

Rs. 50,211.00
SKU stj93869

General Information

Product name Anti-Ku-86 antibody
Short Description
Description Rabbit polyclonal to Ku-86.
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000
Protein Name Anti-Ku-86 antibody
Immunogen Synthesized peptide derived from human Ku-86
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 80 kDa
Database Links
Alternative Names X-ray repair cross-complementing protein 5 antibody
86 kDa subunit of Ku antigen antibody
ATP-dependent DNA helicase 2 subunit 2 antibody
ATP-dependent DNA helicase II 80 kDa subunit antibody
CTC box-binding factor 85 kDa subunit antibody
CTC85 antibody
CTCBF antibody
DNA repair protein XRCC5 antibody
Ku80 antibody
Ku86 antibody
Lupus Ku autoantigen protein p86 antibody
Nuclear factor IV antibody
Thyroid-lupus autoantigen antibody
TLAA antibody
X-ray repair complementing defective repair in Chinese hamster cells 5 antibody
double-strand-break rejoining antibody
G22P2 antibody
Function Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together . The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression . The XRCC5/6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription .
Cellular Localization Nucleus Nucleus, nucleolus Chromosome
Tissue Specificity
Swiss-Prot Key

 

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