Anti-LCN2 antibody

Rs. 73,168.00
SKU stj4001400

General Information

Product name Anti-LCN2 antibody
Short Description Mouse monoclonal to LCN2
Description Neutrophil gelatinase-associated lipocalin (NGAL) is a small glycoprotein expressed in the bone marrow, epithelial tissues associated with antimicrobial defense, and in the distal tubules and collecting duct of the kidney. Elevated levels of blood and urine NGAL are associated with acute or chronic renal failure.
Applications ELISA
Dilution range
Protein Name Anti-LCN2 antibody
Immunogen human neutrophil gelatinase-associated lipocalin (NGAL)
Storage Instruction Unspecified, storage at 2–8 °C
Type of Usage For Research Use Only (RUO).

Product Properties

Host Mouse
Clonality Monoclonal
Reactivity
Conjugation Unconjugated
Purification Purity accurate to >= 95 %
Isotype IgG1
Formulation 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative

Target

Gene ID
Gene Symbol
Molecular Weight 22.6 kDa
Database Links
Alternative Names Neutrophil gelatinase-associated lipocalin antibody
NGAL antibody
25 kDa alpha-2-microglobulin-related subunit of MMP-9 antibody
Lipocalin-2 antibody
Oncogene 24p3 antibody
Siderocalin LCN2 antibody
p25 antibody
HNL antibody
NGAL antibody
Function Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development, Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context, Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration, In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration, Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis, Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth,
Cellular Localization Secreted,
Tissue Specificity Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes.
Swiss-Prot Key

 

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