Anti-LDB3 Antibody

Rs. 45,619.00
SKU stj29598

General Information

Product name Anti-LDB3 Antibody
Short Description Rabbit polyclonal to LDB3
Description This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-LDB3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human LDB3 (NP_001073585.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 77.1 kDa
Database Links
Alternative Names LDB3LIM domain-binding protein 3 antibodyProtein cypher antibodyZ-band alternatively spliced PDZ-motif proteinLDB3 antibodyKIAA0613 antibodyZASP
Function May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
Cellular Localization Cytoplasm, perinuclear region.
Tissue Specificity Expressed primarily in skeletal muscle and to a lesser extent in heart, also detected in brain and placenta.
Swiss-Prot Key

 

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