Anti-LEP Antibody

Rs. 45,619.00
SKU stj27640

General Information

Product name Anti-LEP Antibody
Short Description Rabbit polyclonal to LEP
Description This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
Applications IHC
Dilution range IHC 1:50 - 1:200
Protein Name Anti-LEP Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 22-167 of human LEP (NP_000221.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 18.6 kDa
Database Links
Alternative Names LEPLeptin antibodyObese protein antibodyObesity factorLEP antibodyOB antibodyOBS
Function Key player in the regulation of energy balance and body weight control, Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways.
Cellular Localization Secreted
Tissue Specificity Adipose tissue is the main source of leptin it is also produced by other peripheral tissues such as the skeletal muscle.
Swiss-Prot Key

 

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