Anti-LIMK2 Antibody

Rs. 45,619.00
SKU stj27362

General Information

Product name Anti-LIMK2 Antibody
Short Description Rabbit polyclonal to LIMK2
Description There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-LIMK2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human LIMK2 (NP_001026971.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 72.2 kDa
Database Links
Alternative Names LIMK2LIM domain kinase 2 antibodyLIMK-2LIMK2
Function Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.
Cellular Localization Isoform LIMK2a: Cytoplasm, Nucleus, Isoform LIMK2b: Cytoplasm, Nucleus.
Tissue Specificity Highest expression in the placenta
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF