Anti-Lipocalin 2 Antibody

Rs. 68,577.00
SKU stj71422

General Information

Product name Anti-Lipocalin 2 Antibody
Short Description Goat polyclonal to Lipocalin 2 / NGAL (mouse)
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-Lipocalin 2 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 22.9 kDa
Database Links
Alternative Names Anti-Lipocalin 2 / NGAL (mouse) Antibody
Function Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development, Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context, Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration, In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration, Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis, Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth,
Cellular Localization Secreted,
Tissue Specificity Detected in lung, spleen, uterus, vagina and epididymis,
Swiss-Prot Key

 

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