Anti-LRAT Antibody

Rs. 45,619.00
SKU stj28730

General Information

Product name Anti-LRAT Antibody
Short Description Rabbit polyclonal to LRAT
Description The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:100
Protein Name Anti-LRAT Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-194 of human LRAT (NP_004735.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 25.7 kDa
Database Links
Alternative Names LRATLecithin retinol acyltransferase LRAT
Function Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters, Retinyl esters are storage forms of vitamin A, LRAT plays a critical role in vision, It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium
Cellular Localization Endoplasmic reticulum membrane.
Tissue Specificity Hepatic stellate cells and endothelial cells (at protein level), found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon, low expression observed in brain, in fetal tissues, expressed in retinal pigment epithelium and liver, and barely in the brain.
Swiss-Prot Key

 

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