Anti-LRP5 Antibody

Rs. 45,619.00
SKU stj29785

General Information

Product name Anti-LRP5 Antibody
Short Description Rabbit polyclonal to LRP5
Description This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
Protein Name Anti-LRP5 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1000-1250 of human LRP5 (NP_002326.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 179.1 kDa
Database Links
Alternative Names LRP5Low-density lipoprotein receptor-related protein 5 antibodyLRP-5LRP5 antibodyLR3 antibodyLRP7
Function Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes, Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation, Plays a role in norrin (NDP) signal transduction.
Cellular Localization Membrane
Tissue Specificity Widely expressed, with the highest level of expression in the liver and in aorta.
Swiss-Prot Key

 

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