Anti-LRP6 antibody

Rs. 45,619.00
SKU stj27887

General Information

Product name Anti-LRP6 antibody
Short Description Rabbit polyclonal to LRP6
Description This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-LRP6 antibody
Immunogen A synthetic peptide of human LRP6
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 180.429 kDa
Database Links
Alternative Names Low-density lipoprotein receptor-related protein 6 antibody
LRP-6 antibody
Function Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes, Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation, The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin, Required for posterior patterning of the epiblast during gastrulation ,
Cellular Localization Cell membrane,
Tissue Specificity Widely coexpressed with LRP5 during embryogenesis and in adult tissues
Swiss-Prot Key

 

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