Anti-LRP6 Antibody

Rs. 68,577.00
SKU stj70616

General Information

Product name Anti-LRP6 Antibody
Short Description Goat polyclonal to LRP6
Description
Applications ELISA, IHC
Dilution range
Protein Name Anti-LRP6 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 180.4 kDa
Database Links
Alternative Names LRP6Low-density lipoprotein receptor-related protein 6 antibodyLRP-6LRP6
Function Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes, Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation, The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin, Required for posterior patterning of the epiblast during gastrulation (By similarity),
Cellular Localization Cell membrane,
Tissue Specificity Widely coexpressed with lrp5 during embryogenesis and in adult tissues
Swiss-Prot Key

 

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