Anti-MAGEA1 Antibody

Rs. 45,619.00
SKU stj27423

General Information

Product name Anti-MAGEA1 Antibody
Short Description Rabbit polyclonal to MAGEA1
Description This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:100
Protein Name Anti-MAGEA1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human MAGEA1 (NP_004979.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 34.3 kDa
Database Links
Alternative Names MAGEA1Melanoma-associated antigen 1 antibodyAntigen MZ2-E antibodyCancer/testis antigen 1.1 antibodyCT1.1 antibodyMAGE-1 antigenMAGEA1 antibodyMAGE1 antibodyMAGE1A
Function May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1, May inhibit notch intracellular domain (NICD) transactivation, May play a role in embryonal development and tumor transformation or aspects of tumor progression, Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Cellular Localization Cytoplasm, Nucleus
Tissue Specificity Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes, never expressed in kidney tumors, leukemias and lymphomas
Swiss-Prot Key

 

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