Anti-MAP2K5 Antibody

Rs. 45,619.00
SKU stj29033

General Information

Product name Anti-MAP2K5 Antibody
Short Description Rabbit polyclonal to MAP2K5
Description The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:100
Protein Name Anti-MAP2K5 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human MAP2K5 (NP_660143.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 50.1 kDa
Database Links
Alternative Names MAP2K5Dual specificity mitogen-activated protein kinase kinase 5 antibodyMAP kinase kinase 5 antibodyMAPKK 5MAP2K5 antibodyMEK5 antibodyMKK5 antibodyPRKMK5
Function Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex, Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.
Cellular Localization
Tissue Specificity Expressed in many adult tissues, abundant in heart and skeletal muscle
Swiss-Prot Key

 

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