Anti-MAP3K7 Antibody

Rs. 68,577.00
SKU stj70932

General Information

Product name Anti-MAP3K7 Antibody
Short Description Goat polyclonal to MAP3K7
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-MAP3K7 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 67.2 kDa
Database Links
Alternative Names MAP3K7Mitogen-activated protein kinase kinase kinase 7 MAP3K7 antibodyTAK1
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway, Plays an important role in the cascades of cellular responses evoked by changes in the environment, Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR), Ceramides are also able to activate MAP3K7/TAK1, Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7, These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK), Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK, MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis, In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B, Promotes TRIM5 capsid-specific restriction activity,
Cellular Localization Cytoplasm,
Tissue Specificity Isoform 1a is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells, isoform 1b is highly expressed in brain, kidney and small intestine, isoform 1c is the major form in prostate, isoform 1d is the less abundant form,
Swiss-Prot Key

 

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