Anti-MAPK9 Antibody

Rs. 68,577.00
SKU stj72746

General Information

Product name Anti-MAPK9 Antibody
Short Description Goat polyclonal to MAPK9
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-MAPK9 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 48.1 kDa
Database Links
Alternative Names MAPK9Mitogen-activated protein kinase 9 antibodyMAP kinase 9 antibodyMAPK 9MAPK9 antibodyJNK2 antibodyPRKM9 antibodySAPK1A
Function Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death, Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway, In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2, In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity, In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3, Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1, In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells, Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels, Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption, When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway, Participates also in neurite growth in spiral ganglion neurons, Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock ,
Cellular Localization Cytoplasm
Tissue Specificity
Swiss-Prot Key

 

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